This is usually framed as good versus cheap. It is really a question about heat, colour and how much styling a wearer wants to do.
What human hair gives you
Heat styling, cutting and blending, and darkening with a colour service.
Long life when it is cared for, and the closest movement to growing hair.
What it asks in return
Restyling after every wash. Hair has no style memory, and neither does this.
What synthetic gives you
Style memory: it comes out of the wash in the style it went in.
Heat-friendly fibre reshapes below a stated temperature.
What it cannot do
It cannot be lifted lighter, and it will not take a colour service.
Above its heat ceiling it is destroyed, not damaged.
Choose by the wearer
Somebody who styles daily wants hair. Somebody who wants to wash and go wants fibre.